Azadine 150mg Injection contains Azacitidine, is a chemotherapy agent commonly used for treating certain blood disorders, particularly myelodysplastic syndromes (MDS) and some cases of acute myeloid leukemia (AML). As an inhibitor of DNA methyltransferase, azacitidine targets aberrant cells to halt their growth and encourage cell death.

Brand Name: Azadine

Composition: Azacitidine

Mechanism of Action:

Azacitidine inhibits DNA methyltransferase enzymes by acting as a hypomethylating agent. This results in DNA hypomethylation, which can normalize cell proliferation or cell death by reactivating tumor suppressor genes that are typically repressed in cancer cells. Additionally, it combines with RNA to prevent the creation of proteins in cells that divide quickly.

Uses:

• Myelodysplastic Syndromes
• Acute Myeloid Leukemia

Dosage and Administration:

The administration method is either intravenous infusion or subcutaneous injection. typically given seven days in a row every 28 days, or in accordance with a personalized regimen based on the needs and reaction of the patient.

Side Effects:

• Fatigue
• Weakness
• Nausea
• Vomiting
• Loss of appetite
• Diarrhea
• Constipation
• Anemia
• Neutropenia
• Thrombocytopenia
• Injection site reactions (redness, pain, or swelling)

Safety Advise:

Liver  

Use with caution in patients with hepatic impairment, dose adjustments may be required. Kindly speak with your healthcare provider.

Kidney  

Use with caution in patients with renal impairment, dose adjustments may be required. Kindly speak with your healthcare provider.

Pregnancy  

Azadine causes a risk to the fetus and should not be used during pregnancy. Kindly speak with your healthcare provider.

Breast Feeding  

Azadine should not be taken when nursing because it tends to affect the infant through the breast milk. Kindly speak with your healthcare provider.

Alcohol  

Alcohol use should be avoided when using Azadine since it may make you dizzy. Kindly speak with your healthcare provider.

Storage:

Store below 25°C, away from light.

How to use this Medication:

A medical practitioner administers azacitidine by subcutaneous or intravenous injection, usually once daily for seven days, with cycles repeated every four weeks as advised. Typically, treatment lasts for a minimum of four cycles.

After two cycles, if your condition has not improved and you have not encountered any severe adverse effects from the medicine, your doctor may decide to increase your dosage of azacitidine. If you have certain adverse effects, your doctor could also need to lower your dosage or postpone your treatment. Throughout your azacitadine treatment, be sure to update your doctor about your feelings.

 

Prior to each dose of azacitadine, your doctor will prescribe medication to prevent nausea and vomiting.

Disclaimer:

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