Synvisc ONE Injection contains Hylan G-F 20, which is a viscosupplement composed of Hylan polymers A and B. Patients with osteoarthritis (OA) who have not reacted well to basic painkillers or physical therapy can use it as an intra-articular injection to reduce knee pain.

Brand Name: Synvisc ONE

Composition: Hylan G-F 20

Mechanism of Action:

Synvisc-One helps osteoarthritic joints regain their synovial fluid's viscoelastic characteristics. It enhances joint function by serving as a lubricant during motion and a shock absorber during mechanical stress. By simulating the natural hyaluronic acid, which is usually lacking in joints affected by osteoarthritis, Synvisc-One helps improve mobility and lessen pain related to the condition.

Uses:

Osteoarthritis

Dosage and Administration:

One 6-ml injection (the whole contents of a single prefilled syringe). Route: Only the knee joint will get an intra-articular (IA) injection.

Side Effects:

·       Joint pain

·       Swelling at the injection site

·       Redness around the joint

·       Joint effusion

·       Rash or itching

Safety Advise:

Lungs  

The safety of Synvisc one Injection for individuals with lung issues is uncertain. Kindly speak with your healthcare provider.

Liver  

The safety of Synvisc one Injection for individuals with liver issues is uncertain. Kindly speak with your healthcare provider.

Kidney  

The safety of Synvisc one Injection for individuals with Kidney issues is uncertain. Kindly speak with your healthcare provider.

Pregnancy  

Synvisc one should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

Breast Feeding  

Using Synvisc one while nursing is most likely dangerous. Kindly speak with your healthcare provider. 

Storage:

Keep at room temperature, between 15°C and 30°C. Avoid freezing. Keep out of the direct sun.

How to use this Medication?

This medication is intended to be injected into the knee. In a hospital or clinic, a medical practitioner administers it.

Consult your pediatrician about this medication's use in kids. The use of this medication in minors is not authorized.

References:

1.      Adams ME, Atkinson MH, Lussier AJ, Schulz JI, Siminovitch KA, Wade JP, Zummer M. The role of viscosupplementation with hylan GF 20 (Synvisc®) in the treatment of osteoarthritis of the knee: a Canadian multicenter trial comparing hylan GF 20 alone, hylan GF 20 with non-steroidal anti-inflammatory drugs (NSAIDs) and NSAIDs alone. Osteoarthritis and cartilage. 1995 Dec 1;3(4):213-25.

2.      Migliore A, Giovannangeli F, Granata M, Lagana B. Hylan gf 20: review of its safety and efficacy in the management of joint pain in osteoarthritis. Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders. 2010 Jan;3:117954411000300001.

3.      Clarke S, Lock V, Duddy J, Sharif M, Newman JH, Kirwan JR. Intra-articular hylan GF 20 (Synvisc®) in the management of patellofemoral osteoarthritis of the knee (POAK). The Knee. 2005 Jan 1;12(1):57-62.

Disclaimer:

The main goal of Apothecare Wellness is to make sure that the information it provides to customers is correct, reliable, and reviewed by specialists. This website's contents and information are strictly for informational purposes. They are not meant to be used in place of expert medical advice, diagnosis, or care. Please consult your physician for guidance and ask any questions you may have about any condition or medication. If you read anything on Apothecare Wellness, do not discount or delay obtaining competent medical advice. Our goal is to enhance the doctor-patient relationship, not to take its place.

Marketer details

Name: Sanofi India Ltd

Address: Sanofi House, CTS No.117-B, L&T Business Park, Saki Vihar Road, Powai, Mumbai 400072

Country of origin: India