Tegonat 15mg Capsules containing the active constituents Tegafur, Gimeracil, and Oteracil are used as anticancer drugs, particularly in the treatment of certain types of cancers such as gastric, colorectal, and other solid tumors.
Inform your doctor if you have blood disorders, kidney issues, viral infections, or dihydropyrimidine dehydrogenase (DPD) deficiency. The Tegoyes 15mg Capsule contains lactose, so mention any sugar intolerance, and use contraception during treatment and for six weeks after.
Tegonat 15mg Capsules containing the active constituents Tegafur, Gimeracil, and Oteracil are used as anticancer drugs, particularly in the treatment of certain types of cancers such as gastric, colorectal, and other solid tumors.
Brand Name: Tegonat
Composition: Tegafur, Gimeracil, Oteracil
Mechanism of Action:
Tegafur is metabolized into 5-FU in the body, which inhibits thymidylate synthase, an enzyme essential for DNA synthesis in cancer cells, leading to cell death. Gimeracil enhances the anticancer effects of 5-FU by preventing its rapid degradation, allowing for prolonged exposure of cancer cells to the active drug. Oteracil protects normal tissues, especially the gastrointestinal tract, from the toxic effects of 5-FU, minimizing side effects like severe diarrhea and mucositis.
Uses:
Dosage and Administration:
Administered orally, usually in cycles as per oncologist recommendations, which vary based on cancer type, stage, and patient tolerance.
Side Effect:
Safety Advises:
Liver 
Periodic tests for liver function are recommended as the drug can cause toxicity, especially in patients with pre-existing conditions. Kindly speak with your healthcare provider.
Kidney
Periodic tests for kidney function are recommended as the drug can cause toxicity, especially in patients with pre-existing conditions. Kindly speak with your healthcare provider.
Pregnancy
Tegonat is contraindicated in pregnancy due to the risk of fetal harm. Kindly speak with your healthcare provider.
Breast Feeding
Breastfeeding should be avoided, as the drug can be excreted in breast milk. Kindly speak with your healthcare provider.
Storage:
Store in a cool environment with temperatures between 20°C and 25°C (68°F to 77°F). Protect from moisture, heat, and light. Do not freeze. Keep the medication in its original packaging until ready for use.
References:
1. Kobayakawa M, Kojima Y. Tegafur/gimeracil/oteracil (S-1) approved for the treatment of advanced gastric cancer in adults when given in combination with cisplatin: a review comparing it with other fluoropyrimidine-based therapies. OncoTargets and therapy. 2011 Nov 15:193-201.
2. Sakagashira M. Gimeracil/oteracil/tegafur. Reactions. 2014 Dec;1531:97-13.
3. Osawa H. Gimeracil/oteracil/tegafur. Reactions. 2013 Aug 31;1467:19-20.
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Marketer details
Name: Natco Pharma Ltd
Address: Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Country of origin: India
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