Difidox 100mg Injection contains Doxycycline is a broad-spectrum tetracycline antibiotic. It is frequently used to treat a variety of bacterial infections, such as those brought on by susceptible microorganisms, skin infections, respiratory tract infections, and STDs.

Brand Name: Difidox

Composition: Doxycycline

Mechanism of Action:

Doxycycline is an antibiotic belonging to the tetracycline class that prevents bacteria from synthesizing proteins. By attaching itself to the bacterial 30S ribosomal subunit, it prevents aminoacyl-tRNA from joining the mRNA-ribosome complex. This effectively stops bacterial growth by preventing amino acids from being added to the expanding peptide chain (bacteriostatic action).

Uses:

·       Respiratory tract infections

·       Urinary tract infections

·       Skin and soft tissue infections

·       Certain sexually transmitted infections

·       Rickettsial infections

·       Malaria prophylaxis

Dosage and Administration:

Given by intravenous (IV) infusion; usually, it is diluted and given over a period of one to four hours. The kind and severity of the infection determine the dosage and length of time.

Side Effects:

·       Nausea

·       Vomiting

·       Diarrhea

·       Abdominal pain

·       Loss of appetite

·       Rash

·       Dry mouth

·       Esophagitis

Safety Advise:

Lungs  

The safety of Difidox Injection for individuals with lung issues is uncertain. Kindly speak with your healthcare provider.

Liver  

The safety of Difidox Injection for individuals with liver issues is uncertain. Kindly speak with your healthcare provider.

 Kidney  

The safety of Difidox Injection for individuals with Kidney issues is uncertain. Kindly speak with your healthcare provider.

Pregnancy  

Difidox should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

Breast Feeding  

Using Difidox while nursing is most likely dangerous. Kindly speak with your healthcare provider. 

Storage:

Keep out of direct sunlight and store below 25°C. Keep out of children's reach.

How to use this Medication?

The injection form of doxycycline is a powder that is combined with a liquid and administered intravenously (into a vein). Over a period of one to four hours, it is typically administered every twelve or twenty-four hours. The type of illness you have and how your body reacts to the medication will determine how long your treatment will last.

You can give the drug at home or have an injection of doxycycline in a hospital. Your healthcare professional will demonstrate how to utilize the drug if you will be receiving doxycycline injections at home. Make sure you comprehend these instructions, and if you have any concerns, consult your healthcare practitioner.

References:

1.     Cunha BA, Sibley CM, Ristuccia AM. Doxycycline. Therapeutic drug monitoring. 1982 Jun 1;4(2):115.

2.     Blanchard P, Rudhardt M, Fabre J. Behaviour of doxycycline in the tissues. Chemotherapy. 1975 Jan 1;21(Suppl 1):8-18.

3.     Abd El-Aty AM, Goudah A, Zhou HH. Pharmacokinetics of doxycycline after administration as a single intravenous bolus and intramuscular doses to non-lactating Egyptian goats. Pharmacological research. 2004 May 1;49(5):487-91.

4.     Majewski M. A current opinion on the safety and efficacy of doxycycline including parenteral administration–A review. Polish Annals of Medicine. 2014 Jun 1;21(1):57-62.

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