Akynzeo 300mg/0.5mg Capsule is a fixed-dose combination medication containing Netupitant (300mg) and Palonosetron (0.5mg). It is used to prevent nausea and vomiting brought on by chemotherapy for cancer, including chemotherapy that is both severely and mildly emetogenic.
If you are pregnant or nursing, let your doctor know. Patients with liver and kidney disorders should not take this medication. If you have a medical condition or are on medication, let your doctor know. Because this medication may cause drowsiness or vertigo, it is strongly discouraged that you drive or operate heavy machinery while undergoing therapy.
Akynzeo 300mg/0.5mg Capsule is a fixed-dose combination medication containing Netupitant (300mg) and Palonosetron (0.5mg). It is used to prevent nausea and vomiting brought on by chemotherapy for cancer, including chemotherapy that is both severely and mildly emetogenic.
Brand Name: Akynzeo
Composition: Netupitant (300mg), Palonosetron (0.5mg)
Mechanism of Action:
Netupitant and Palonosetron work together to prevent chemotherapy-induced nausea and vomiting (CINV) by targeting different phases of the condition. Netupitant lessens the effects of substance P, a major contributor to the delayed phase of CINV, by blocking NK1 receptors in the central nervous system. In the meanwhile, palonosetron successfully stops the acute phase of CINV by blocking 5-HT3 receptors in the brain and gastrointestinal system. Comprehensive protection against chemotherapy-related nausea and vomiting is offered by this dual mechanism.
Uses:
Nausea and Vomiting due to chemotherapy
Dosage and Administration:
Take one capsule orally about an hour prior to treatment.
Side Effects:
Safety Advise:
Liver 
Liver function should be monitored regularly, as Akynzeo can cause abnormalities in liver. Kindly speak with your healthcare provider.
Kidney
Kidney function should be monitored regularly, as Akynzeo can cause abnormalities in kidney. Kindly speak with your healthcare provider.
Pregnancy
Akynzeo should not be used while pregnant due to the potential harm it can cause to the fetus. Kindly speak with your healthcare provider.
Breastfeeding
When using this drug, it is not advised. If you are or will be breastfeeding, Kindly speak with your healthcare provider.
Driving
Akynzeo may make you tired or dizzy. Till you understand how the medicine affects you. Kindly speak with your healthcare provider.
Storage:
Store Akynzeo at room temperature, away from moisture and heat.
Disclaimer:
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Marketer details
Name: Glenmark Pharmaceuticals Ltd
Address: Glenmark Pharmaceuticals Limited, B/2, Mahalaxmi Chambers, 22, Bhulabhai Desai Road, Mumbai – 400 026.
Country of origin: Ireland
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