Targocid 200mg Injection contains Teicoplanin, an antibiotic used to treat a wide range of bacterial infections, particularly those caused by Gram-positive bacteria. It works particularly well against methicillin-resistant Staphylococcus aureus (MRSA) and other antibiotic-resistant infections.

Brand Name: Targocid

Composition: Teicoplanin

Mechanism of Action:

Teicoplanin functions by preventing the synthesis of bacterial cell walls. By attaching itself to the peptidoglycan of the bacterial cell wall's D-alanyl-D-alanine residues, it stops cross-linking and kills the bacterium. When it comes to Gram-positive bacteria, this method works especially well.

Uses:

• Septicemia (blood infections)
• Endocarditis (heart valve infection)
• Bone and joint infections
• Respiratory tract infections
• Skin and soft tissue infections
• Urinary tract infections

Dosage and Administration:

Administered intravenously, Dosage varies based on the type and severity of the infection, renal function, and patient age. It is usually given every 8 hours.

Side Effects:

·       Nausea

·       Vomiting

·       Diarrhea

·       Rash

·       Headache

·       Allergic reactions

·       Seizures

·       Thrombocytosis

Safety Advise:

Kidney  

Teicoplanin is primarily excreted by the kidneys, so dose adjustments are required in patients with renal impairment. Kindly speak with your healthcare provider.

Liver  

Liver function tests should be monitored during prolonged treatment, especially in patients with liver disease, as meropenem can cause elevated liver enzymes. Kindly speak with your healthcare provider.

Pregnancy  

Use Teicoplanin during pregnancy only if clearly needed and under medical supervision, as its safety during pregnancy is not fully established.  Kindly speak with your healthcare provider.

Breast Feeding  

Caution is advised during breastfeeding since the drug can pass into breast milk. Kindly speak with your healthcare provider.

Driving  

Your ability to drive may be impacted by injection side effects. Kindly speak with your healthcare provider.

Storage:

Store in a cool and dry place away from sunlight. Store the vials at room temperature before reconstitution. Once reconstituted, the solution should be used within a specific time frame as recommended by the manufacturer to ensure stability and effectiveness.

References:

1.      Wilson AP. Clinical pharmacokinetics of teicoplanin. Clinical pharmacokinetics. 2000 Sep;39:167-83.

2.      Shea KW, Cunha BA. Teicoplanin. The Medical clinics of North America. 1995 Jul 1;79(4):833-44.

3.      Davey PG, Williams AH. A review of the safety profile of teicoplanin. Journal of Antimicrobial Chemotherapy. 1991 Jan 1;27(suppl_B):69-73.

4.     Campoli-Richards DM, Brogden RN, Faulds D. Teicoplanin: a review of its antibacterial activity, pharmacokinetic properties and therapeutic potential. Drugs. 1990 Sep;40(3):449-86.

5.      Parenti F, Schito GC, Courvalin P. Teicoplanin chemistry and microbiology. Journal of Chemotherapy. 2000 Nov 1;12(sup5):5-14.

Disclaimer:

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Marketer details

Name: Sanofi India Ltd

Address: Sanofi House, CTS No.117-B, L&T Business Park, Saki Vihar Road, Powai, Mumbai 400072

Country of origin: Italy