Enfiera 500mg Injection contains Rituximab, a monoclonal antibody used to treat certain types of cancers and autoimmune diseases. 

Brand Name: Enfiera

Composition: Rituximab

Mechanism of Action:

Rituximab targets the CD20 antigen on B-lymphocytes (B-cells), which are involved in both normal immune function and the development of certain cancers like non-Hodgkin's lymphoma and CLL. Upon binding to CD20, rituximab induces B-cell death through multiple pathways, including direct apoptosis (cell death), activation of the complement system, and recruitment of immune cells that kill the antibody-tagged B-cells.

Uses:

·         Non-Hodgkin’s Lymphoma

·         Chronic Lymphocytic Leukemia

·         Rheumatoid Arthritis

·         Granulomatosis with Polyangiitis (GPA) and Microscopic Polyangiitis (MPA) Pemphigus Vulgaris

Side Effects:

·         Skin rash

·         Itching

·         Hives

·         Swelling of the face, lips, or tongue

·         Diarrhea

·         Edema

·         Weight gain

·         Trouble breathing

·         Irregular heartbeat

·         Heart attack

·         Fever

·         Chills

·         Cough

·         Sore throat

Safety Advise:

Liver  

Information regarding the use of Enfiera 500mg Injection in liver disease patients is minimal. Kindly speak with your healthcare provider.

Kidney  

Information regarding the use of Enfiera 500mg Injection in kidney disease patients is minimal. Kindly speak with your healthcare provider.

Pregnancy  

Rituximab should only be used during pregnancy if clearly needed, as it can harm the fetus. Kindly speak with your healthcare provider.

Breastfeeding  

Nursing mothers should not get a 500mg injection of Enfiera unless truly necessary. Kindly speak with your healthcare provider.

Alcohol  

When using Enfiera 500mg Injection with alcohol, caution is suggested. Kindly speak with your healthcare provider.

Storage:

Store in a refrigerator between 2°C to 8°C. Do not freeze or shake the vial.

How to use this medication?

This medication is administered through a vein by a healthcare professional in a hospital or clinic setting.

You will receive a special Medication Guide before each treatment, so make sure to read it thoroughly every time.

Consult your healthcare provider about using this medication for children. While it may be prescribed to children as young as 6 months for certain conditions, specific precautions must be followed.

In case of an overdose, immediately contact a poison control center or go to the emergency room.

References:

1.      Weiner GJ. Rituximab: mechanism of action. InSeminars in hematology 2010 Apr 1 (Vol. 47, No. 2, pp. 115-123). WB Saunders.

2.      Kimby E. Tolerability and safety of rituximab (MabThera®). Cancer treatment reviews. 2005 Oct 1;31(6):456-73.

3.      Cohen MD, Keystone E. Rituximab for rheumatoid arthritis. Rheumatology and therapy. 2015 Dec;2:99-111.

4.      Mok CC. Rituximab for the treatment of rheumatoid arthritis: an update. Drug design, development and therapy. 2014 Dec 27:87-100.

Disclaimer:

The main goal of Apothecare Wellness is to make sure that the information it provides to customers is correct, reliable, and reviewed by specialists. This website's contents and information are strictly for informational purposes. They are not meant to be used in place of expert medical advice, diagnosis, or care. Please consult your physician for guidance and ask any questions you may have about any condition or medication. If you read anything on Apothecare Wellness, do not discount or delay obtaining competent medical advice. Our goal is to enhance the doctor-patient relationship, not to take its place.

Marketer details

Name: Zydus Lifesciences Ltd

Address: Zydus Corporate Park, 4Th Floor, B Wing, Plot No 103, Near Nirma University,S G Highway, Ahmedabad, 382481

Country of origin: India