Tucaone 150mg Tablet

Tucaone 150mg Tablet contains Tucatinib, a targeted therapy used in oncology. This tyrosine kinase inhibitor (TKI) is used particularly to treat advanced or metastatic breast cancer that is HER2-positive. It has also been investigated for HER2-positive gastrointestinal malignancies.

Brand Name: Tucaone

Composition: Tucatinib

Mechanism of Action:

Mutations in the HER-2 gene are observed in some types of breast carcinoma. Tucatinib inhibits the HER-2 gene's tyrosine kinase enzyme. Mutations in the HER-2 tyrosine kinase gene cause a cascade of enhanced cell signaling and proliferation, leading in malignancy. In vitro studies suggest that tucatinib inhibits both HER-2 and HER-3 phosphorylation, resulting in downstream alterations in MAPK and AKT signaling and cell proliferation. Anti-tumor action was observed in cells that expressed HER-2. Tucatinib has been found in vivo to suppress HER-2 expressing tumors, most likely through the same mechanism.

Uses:

HER2-positive Advanced or Metastatic breast cancer

Dosage and Administration:

The standard dose is 150 mg orally twice daily, with or without food.

Side Effects:

·       Diarrhea

·       Rash, redness, pain, swelling on the palms of your hands or soles of your feet

·       Nausea

·       Vomiting

·       Mouth sores

·       Decreased appetite

·       Anemia

·       Rash

Safety Advise:

Lungs   

The safety of Tucaone Tablet for individuals with lung issues is uncertain. Kindly speak with your healthcare provider.

Liver  

The safety of Tucaone Tablet for individuals with liver issues is uncertain. Kindly speak with your healthcare provider.

Kidney  

The safety of Tucaone Tablet for individuals with Kidney issues is uncertain. Kindly speak with your healthcare provider.

Pregnancy  

Tucaone Tablet should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

Breast Feeding  

Using Tucaone Tablet while nursing is most likely dangerous. Kindly speak with your healthcare provider. 

Storage:

Store at room temperature in a dry location out of direct sunlight.

How to use this Medication?

Tucatinib is available in the form of an orally administered tablet. It is often taken with or without food twice a day, roughly 12 hours apart. Take tucatinib at the same times every day. Follow the instructions on your prescription label carefully, and ask your doctor or pharmacist to explain any parts you don't understand. Take tucatinib precisely as prescribed. Do not take more or less of it, or take it more frequently than recommended by your doctor.

Swallow the pills whole, without splitting, chewing, or crushing them. Avoid taking tablets that are broken, cracked, or damaged in any way.


If you vomit after taking tucatinib, you should not take another dose. Continue with your regular dose schedule.

Reference:

1.     Shah M, Wedam S, Cheng J, Fiero MH, Xia H, Li F, Fan J, Zhang X, Yu J, Song P, Chen W. FDA approval summary: tucatinib for the treatment of patients with advanced or metastatic HER2-positive breast cancer. Clinical cancer research. 2021 Mar 1;27(5):1220-6.

2.     Sirhan Z, Thyagarajan A, Sahu RP. The efficacy of tucatinib-based therapeutic approaches for HER2-positive breast cancer. Military Medical Research. 2022 Jul 13;9(1):39.

Disclaimer:

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Marketer details

Name: MSN Laboratories

Address: MSN House, Plot No: C-24, Industrial Estate, Sanathnagar, Hyderabad - 18 Telangana, India

Country of origin: India