Cizumab 400mg Injection contains Bevacizumab, a monoclonal antibody used in cancer therapy. It functions by preventing angiogenesis, which is how cancers create their own blood supply.
If you are pregnant, intend to become pregnant, or are nursing, let your doctor know. Inform your healthcare provider of all the medications you take because this medication can affect or be affected by a number of other medications.
Cizumab 400mg Injection contains Bevacizumab, a monoclonal antibody used in cancer therapy. It functions by preventing angiogenesis, which is how cancers create their own blood supply.
Brand Name: Cizumab
Composition: Bevacizumab
Mechanism of Action:
It seeks out and attaches itself to vascular endothelial growth factor (VEGF), a protein that stimulates blood vessel development. Bevacizumab stops VEGF from attaching to its receptors on endothelial cells, which stops new blood vessels from forming and stops tumor development and metastasis.
Uses:
Dosage and Administration:
Depending on the particular malignancy being treated and the patient's general health, the dosage may change. A gradual intravenous infusion of bevacizumab is administered; the infusion rate can be changed according to the patient's tolerance.
Side Effects:
Safety Advise:
Liver 
Caution is advised in patients with hepatic impairment, and dosage adjustments may be necessary. Kindly speak with your healthcare provider.
Kidney
Caution is advised in patients with renal impairment, and dosage adjustments may be necessary. Kindly speak with your healthcare provider.
Pregnancy
It should only be used if absolutely necessary because its safety during pregnancy has not been thoroughly demonstrated. Kindly speak with your healthcare provider.
Breast Feeding
Using Cizumab Injection while nursing is most likely dangerous. Kindly speak with your healthcare provider.
Alcohol
Alcohol consumption while using Cizumab Injection is not advised. Kindly speak with your healthcare provider.
Storage:
Cizumab Injection should be kept out of direct sunlight and at room temperature, between 20°C and 25°C.
How to use this Medication?
Usually given once every two or three weeks, bevacizumab injection is a liquid that a medical expert administers slowly into a vein. The dosage schedule is customized based on your individual condition and response to treatment.
When the drug is infused, bevacizumab injectable products have the potential to induce severe side effects. Notify your doctor right once if you suffer from any of the following symptoms: headaches, dizziness, chest discomfort, flushing, itching, rash, hives, chills, shaking, sweating, or shortness of breath. If you have these or other side effects, your doctor might need to reduce the rate of your infusion or postpone or terminate your treatment.
References:
1. Burness CB, Duggan ST. Trifluridine/tipiracil: a review in metastatic colorectal cancer. Drugs. 2016 Sep;76:1393-402.
2. Peeters M, Cervantes A, Moreno Vera S, Taieb J. Trifluridine/tipiracil: an emerging strategy for the management of gastrointestinal cancers. Future Oncology. 2018 Jul;14(16):1629-45.
3. Cuissy S, Sefrioui D. Metastatic colorectal cancer: Trifluridine-tipiracil and bevacizumab. The results of the SUNLIGHT study bring an end to the questioning about whether to use trifluridine-tipiracil or regorafenib. Hépato-Gastro & Oncologie Digestive. 2024;31(2):267-72.
4. Jeffers KD. Trifluridine/tipiracil: old drug, new tricks. Journal of the Advanced Practitioner in Oncology. 2016 May;7(4):449.
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