Natdecita 50mg Injection contains the active ingredient Decitabine, an antineoplastic agent used in the treatment of certain types of blood cancers, particularly myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). Decitabine is a cytidine analog that helps normalize blood cell growth and maturation by acting as a hypomethylating agent.

Brand Name: Natdecita

Composition: Decitabine

Mechanism of Action:

The enzyme that causes DNA methylation, DNA methyltransferase, is inhibited by decitabine. Mutations that silence tumor suppressor genes are associated with abnormal DNA methylation. Decitabine promotes cell differentiation and apoptosis in cancerous cells by blocking this process and restoring normal gene function.

Uses:

• Myelodysplastic Syndromes
• Acute Myeloid Leukemia

Dosage and Administration:

Intravenous infusion only. Every six weeks, administer 15 mg/m² intravenously every eight hours for three days. varies according to the patient's reaction and is frequently repeated over multiple cycles.

Side  Effects:

• Anemia
• Neutropenia
• Thrombocytopenia
• Nausea
• Vomiting
• Fatigue
• Fever

Safety Advise:

  Kidney  

Monitor kidney function regularly, as Natdecita can cause nephrotoxicity. Kindly speak with your healthcare provider.

  Liver  

Monitor liver function regularly, as Natdecita can cause liver impairement. Kindly speak with your healthcare provider.

  Pregnancy  

Natdecita should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

  Breast Feeding  

Using Natdecita while nursing is most likely dangerous. Kindly speak with your healthcare provider.

  Alcohol  

Natdecita should not be taken with alcohol. Kindly speak with your healthcare provider.

Storage:

Keep refrigerated (2–8°C). As directed, the reconstituted solution must be used right away or stored for a brief amount of time.

How to use this Medication?

Decitabine is available as a powder that a doctor or nurse can mix with fluid and administer intravenously (into a vein) gradually over three hours in a hospital outpatient clinic or doctor's office. For three days, it is typically injected every eight hours. This course of treatment is known as a cycle, and it can be repeated every six weeks for however long your doctor prescribes. Usually administered for at least four cycles, decitabine may be prolonged if your doctor determines that further treatment may be beneficial.

If you have certain adverse effects, your doctor could also need to lower your dosage and postpone your treatment. Throughout your decitabine treatment, be sure to communicate your feelings to your doctor.

Disclaimer:

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Marketer details

Name: Natco Pharma Ltd

Address: Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India

Country of origin: India