Endace 160mg Tablet contains megestrol acetate, a type of progestin (a synthetic form of the hormone progesterone). It is frequently used to treat various cancers, particularly endometrial and breast cancer, as well as to stimulate appetite.

Brand Name: Endace

Composition: Megestrol acetate

Mechanism of Action:

A synthetic progestin called megestrol acetate functions by attaching itself to progesterone receptors. It works by preventing the pituitary gland's secretion of gonadotropin hormones (FSH and LH), which suppresses ovulation and lowers the generation of estrogen. It may also stimulate hunger by influencing the hypothalamus and has anti-estrogenic properties, which makes it helpful in controlling weight loss in some diseases like AIDS or cancer.

Uses:

Endometrial cancer

Breast cancer

Dosage and Administration:

160 mg once daily, dosage may vary depending on the condition and patient’s response. Taken orally, with or without food.

Side Effects:

• Weight gain
• Increased appetite
• Nausea
• Stomach upset
• Vomiting
• Constipation
• Hot flashes
• Blood clots (deep vein thrombosis, pulmonary embolism)
• Hyperglycemia
• Adrenal insufficiency

Safety Advise:

Heart  

Megestrol acetate may cause fluid retention and edema (swelling), which could exacerbate diseases like high blood pressure, stroke, or cardiovascular disease. As such, patients with a history of these conditions should exercise caution when using this medication. Kindly speak with your Healthcare Professional.

Bone  

Extended usage may lower bone mineral density, raising the possibility of bone fractures and osteoporosis. Kindly speak with your Healthcare Professional.

Liver  

Patients with a history of liver disease should inform their healthcare provider, as megestrol acetate may require typical liver function tests to avoid potential liver complications.

Kidney  

When using Endace 160 Tablet, people with severe kidney disease should take caution. It could be necessary to modify the Endace 160 Tablet's dosage. Kindly speak with your Healthcare Professional.

Pregnancy  

Megestrol acetate is contraindicated in pregnancy as it can cause harm to the developing fetus, leading to birth defects or miscarriage. Kindly speak with your Healthcare Professional.

Breast Feeding  

Endace should not be taken during breastfeeding because the drug may pass into breast milk and could harm the baby. Kindly speak with your Healthcare Professional.

Alcohol  

It is unknown if drinking alcohol while using Endace 160 Tablet is safe. Kindly speak with your Healthcare Professional.

Driving  

Endace may cause dizziness or fatigue. Be cautious when driving until you understand how the medication affects you.

Storage:

Store below 25°C, protected from light and moisture.

How to use this Medication?

Take megestrol tablets by mouth at the same time each day, following your doctor's instructions closely. Do not adjust the dosage or frequency without your doctor's approval.

Do not stop taking megestrol without talking to your doctor.

References:

1.      Schacter L, Rozencweig M, Canetta R, Kelley S, Nicaise C, Smaldone L. Megestrol acetate: clinical experience. Cancer treatment reviews. 1989 Mar 1;16(1):49-63.

2.      Canetta R, Florentine S, Hunter H, Lenaz L. Megestrol acetate. Cancer Treatment Reviews. 1983 Sep 1;10(3):141-57.

3.   Loprinzi CL, Michalak JC, Quella SK, O'fallon JR, Hatfield AK, Nelimark RA, Dose AM, Fischer T, Johnson C, Klatt NE, Bate WW. Megestrol acetate for the prevention of hot flashes. New England Journal of Medicine. 1994 Aug 11;331(6):347-52.

4.      Tchekmedyian NS, Hickman M, Siau J, Greco FA, Keller J, Browder H, Aisner J. Megestrol acetate in cancer anorexia and weight loss. Cancer. 1992 Mar 1;69(5):1268-74.

Disclaimer:

The main goal of Apothecare Wellness is to make sure that the information it provides to customers is correct, reliable, and reviewed by specialists. This website's contents and information are strictly for informational purposes. They are not meant to be used in place of expert medical advice, diagnosis, or care. Please consult your physician for guidance and ask any questions you may have about any condition or medication. If you read anything on Apothecare Wellness, do not discount or delay obtaining competent medical advice. Our goal is to enhance the doctor-patient relationship, not to take its place.

Marketer details

Name: Samarth Life Sciences Pvt Ltd

Address: Samarth House, 168, Bangur Nagar, Off Link Road, Near Ayappa Temple & Kallol Kali Temple, Goregaon (W), Mumbai - 400 090.

Country of origin: India