Gardasil 9 is a recombinant vaccine designed to protect against infections caused by 9 types of Human Papillomavirus (HPV). It is used to avoid genital warts and disorders like cervical, vaginal, vulvar, and anal malignancies that are linked to HPV.

Brand Name: Gardasil

Composition: Human Papillomavirus 9-Valent

Mechanism of Action:

Gardasil 9 is a recombinant HPV vaccine containing L1 Virus-Like Particles (VLPs) for HPV types 6, 11, 16, 18, 31, 33, 45, 52, and 58. Following an intramuscular injection, antigen-presenting cells (APCs) digest the VLPs and trigger T-helper cells, which in turn trigger B cells to generate neutralizing antibodies specific to HPV. These antibodies inhibit the virus's ability to replicate by preventing HPV from invading host epithelial cells. Long-term immunological memory is induced by the vaccine, providing sustained protection against genital warts and malignancies linked to HPV. For more robust and long-lasting protection, aluminum adjuvant strengthens the immune response.

Uses:

·       Cervical cancer

·       Vaginal and vulvar cancers

·       Anal cancer

·       Genital warts  

·       Precancerous or dysplastic lesions

Dosage and Administration:

2 doses for children aged 9 to 14 (0, 6-12 months) and 3 doses (0, 2, 6 months) for those aged 15 to 45. given as an intramuscular (IM) injection into the thigh or deltoid muscle.

Side Effects:

·       Injection site reactions (pain, swelling, redness)

·       Headache

·       Nausea

·       Vomiting

·       Fainting

·       Dizziness

·       Fatigue

·       Mild fever

·       Muscle Pain

·       Joint pain

Safety Advise:

Kidney  

The usage of Gardasil vaccine in individuals with renal dysfunction may lead to serious effect. Kindly speak with your healthcare provider. 

Liver  

The usage of Gardasil vaccine in individuals with liver dysfunction may lead to serious effect. Kindly speak with your healthcare provider.

Pregnancy  

Gardasil vaccine is unsafe to use during pregnancy as there is definite evidence of risk to the developing baby. Kindly speak with your healthcare provider.

Breast Feeding  

Gardasil vaccine is likely dangerous to use an injection while breast feeding. The medication may damage the unborn child if it enters the breastmilk. Kindly speak with your healthcare provider.

Storage:

Store in a refrigerator (2°C to 8°C). Do not freeze.

References:

1.     Cervavac [Quadrivalent Human Papillomavirus (HPV Types 6, 11, 16, & 18) Vaccine.

2.     Human Papillomavirus Quadrivalent (Types 6, 11, 16, and 18) Vaccine [Prescribing Infroamtion]. Whitehouse Station, NJ: Merck Sharp & Dohme Corp; 2015.

Sinha A, Singh S. Immunization and Immunodeficiency. In: Paul VK, Bagga A, editors. Ghai Essential Pediatrics. 8th ed. New Delhi: CBS Publisher's & Distributors Pvt Ltd.; 2013. pp. 200-201.

Disclaimer: 

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Marketer details

Name: MSD Pharmaceuticals Pvt Ltd

Address: Platina, 8th Floor, C.59, G Block, Bandra Kurla Complex, Bandra (East) , Mumbai - 400098,

Country of origin: Netherlands