Merex 1000mg Injection is prescribed drug that contains Methotrexate, an antimetabolite and immunosuppressant. Its main applications are in the treatment of several types of cancer and some autoimmune diseases.

Brand Name: Merex

Composition: Methotrexate

Mechanism of Action:

Methotrexate prevents the production of tetrahydrofolate by inhibiting dihydrofolate reductase (DHFR). This hinders the synthesis of proteins, RNA, and DNA, particularly in cells that divide quickly. It lowers inflammation in autoimmune disorders by raising adenosine levels. Additionally, it inhibits the generation of inflammatory cytokines and T-cell activity.

Uses:

·       Severe psoriasis

·       Used for certain types of Cancer

·       Rheumatoid arthritis

Dosage and Administration:

Dosage of Merex 1000mg Injection vary based on diagnosis, body surface area, and condition of the patient. Under medical supervision, supportive care, and monitoring, it is given intravenously.

Side Effects:

·       Nausea

·       Vomiting

·       Loss of appetite

·       Mouth ulcers

·       Fatigue

·       Dizziness

·       Hair loss

·       Low white blood cell count

·       Liver enzyme elevation

·       Skin rash

·       Itching

·       Anemia

Safety Advise:

Lungs  

The safety of Merex Injection for individuals with lung issues is uncertain. Kindly speak with your healthcare provider.

Liver  

The safety of Merex Injection for individuals with liver issues is uncertain. Kindly speak with your healthcare provider.

Kidney  

The safety of Merex Injection for individuals with Kidney issues is uncertain. Kindly speak with your healthcare provider.

Pregnancy  

Merex should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

  Breast Feeding  

Using Merex while nursing is most likely dangerous. Kindly speak with your healthcare provider. 

Storage:

Store in a refrigerator between 2°C and 8°C. Avoid freezing the injection. Keep out of direct sunlight and in its original packaging until it's time to use it.

How to use this Medication?

Injections of methotrexate can be administered intramuscularly (into a muscle), intravenously (into a vein), subcutaneously (just beneath the skin), or intrathecally (into the spinal canal's fluid-filled space) as a powder that has been combined with liquid. The frequency of your methotrexate injections will be determined by your physician. Your ailment and how your body reacts to the drug will determine the schedule. The length of therapy is determined by the type of cancer or illness you have, the medications you are taking, and how well your body reacts to them.

To avoid or treat methotrexate injection side effects, your doctor may prescribe one or more medications.


Request a copy of the manufacturer's information for the patient from your physician or pharmacist.

References:

1.      Chan ES, Cronstein BN. Methotrexate—how does it really work?. Nature Reviews Rheumatology. 2010 Mar;6(3):175-8.

2.      Cronstein BN. The mechanism of action of methotrexate. Rheumatic disease clinics of North America. 1997 Nov 1;23(4):739-55.

3.      Bischoff KB, Dedrick RL, Zaharko DS, Longstreth JA. Methotrexate pharmacokinetics. Journal of pharmaceutical sciences. 1971 Aug 1;60(8):1128-33.

4.      Kremer JM. Toward a better understanding of methotrexate. Arthritis & Rheumatism. 2004 May;50(5):1370-82.

Disclaimer:

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Marketer details

Name: Intas Pharmaceuticals Ltd

Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.

Country of origin: India