Anvimo 240mg Tablet

Anvimo 240mg Tablet contains Letermovir, an antiviral indicated for preventing cytomegalovirus (CMV) infection in adults who are undergoing hematopoietic stem cell or kidney transplants.

Brand Name: Anvimo

Composition: Letermovir

Mechanism of Action:

Letermovir reduces CMV viral replication by targeting the viral terminase complex, which prevents DNA maturation and packaging. This prevents the virus from replicating. Because it is not active against other viruses, it provides specific CMV inhibition. Better tolerated than previous CMV medications such as ganciclovir.

Uses:

CMV Infection

Dosage and Administration:

The standard dose is 240 mg taken by mouth once a day, starting early after the transplant according to the rules of the transplant center.

Side Effects:

·       Nausea

·       Diarrhea

·       Peripheral edema

·       Cough

·       Vomiting

·       Headache

Safety Advise:

Lungs  

The safety of Anvimo tablet for individuals with lung issues is uncertain. Kindly speak with your healthcare provider.

Liver  

The safety of Anvimo tablet for individuals with liver issues is uncertain. Kindly speak with your healthcare provider.

Kidney  

The safety of Anvimo tablet for individuals with Kidney issues is uncertain. Kindly speak with your healthcare provider.

Pregnancy  

Anvimo tablet should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

Breast Feeding  

Using Anvimo tablet while nursing is most likely dangerous. Kindly speak with your healthcare provider. 

Storage:

Keep out of direct sunlight, heat, and moisture, and store at room temperature below 30°C. Keep out of children's reach.

How to use this Medication?

Letermovir is available as an oral tablet. Typically, it is given once day. You can take letermovir pills with or without food. Letermovir pellets need to be taken orally (without chewing) after being combined with a soft meal. After receiving a transplant, your doctor would likely advise you to begin taking letermovir and to stop taking it 100 or 200 days later. Letermovir should be taken daily at around the same time. Pay close attention to the instructions on your prescription label, and ask your pharmacist or doctor to clarify any parts you don't understand. Letermovir should be taken precisely as prescribed. Never take more or less of it, or take it more frequently than your doctor has suggested.

Reference:

1.      Kim ES. Letermovir: first global approval. Drugs. 2018 Jan;78:147-52.

2.      El Helou G, Razonable RR. Letermovir for the prevention of cytomegalovirus infection and disease in transplant recipients: an evidence-based review. Infection and drug resistance. 2019 Jun 4:1481-91.

3.      Bowman LJ, Melaragno JI, Brennan DC. Letermovir for the management of cytomegalovirus infection. Expert Opinion on Investigational Drugs. 2017 Feb 1;26(2):235-41.

4.      Aitken SL, Saunders R, Chemaly RF, Ehninger G. Letermovir. InKucers' The Use of Antibiotics 2017 Oct 2 (pp. 3619-3626). CRC Press.

Disclaimer:

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Marketer details

Name: Zydus Life Sciences

Address: Zydus Corporate Park, Scheme No. 63, Survey No. 536 Khoraj (Gandhinagar), Nr. Vaishnodevi Circle, SG Highway, Ahmedabad – 382481, Gujarat

Country of origin: India