Velasof Tablet is a combination antiviral medication primarily used in the treatment of chronic hepatitis C infection. It comprises Velpatasvir and Sofosbuvir, which together prevent the hepatitis C virus (HCV) from replicating.
Do not take Velasof tablets if you have a known allergy to it or any of its components. The safety and efficacy of sofosbuvir and velpatasvir in children under 18 are not established, so alternative treatments or dosage adjustments are recommended for this population.
Velasof Tablet is a combination antiviral medication primarily used in the treatment of chronic hepatitis C infection. It comprises Velpatasvir and Sofosbuvir, which together prevent the hepatitis C virus (HCV) from replicating.
Brand Name: Velasof
Composition: Sofosbuvir, Velpatasvir
Mechanism of Action:
By inhibiting the viral RNA polymerase, sofosbuvir, an NS5B polymerase inhibitor, stops the virus from replicating. Velpatasvir is an NS5A inhibitor that prevents the hepatitis C virus from replicating and assembling.
Uses:
Chronic Hepatitis C Infection
Dosage and Administration:
One tablet taken once a day, with or without food, is the usual dosage. The length of treatment varies from 12 to 24 weeks, depending on the virus's genotype and past treatment history.
Side Effects:
Safety Advise:
Kidney 
Monitor kidney function regularly, as Velasof can cause nephrotoxicity. Kindly speak with your healthcare provider.
Liver
Monitor liver function regularly, as Velasof can cause liver impairement. Kindly speak with your healthcare provider.
Pregnancy
Velasof should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.
Breast Feeding
Using Velasof while nursing is most likely dangerous. Kindly speak with your healthcare provider.
Alcohol 
Velasof should not be taken with alcohol. Kindly speak with your healthcare provider.
Storage:
Store Velasof Tablet at a temperature between 15°C and 30°C (59°F to 86°F). Keep the tablets in the original packaging to protect them from light and moisture. Keep out of reach of children.
References:
1. Greig SL. Sofosbuvir/velpatasvir: a review in chronic hepatitis C. Drugs. 2016 Oct;76(16):1567-78.
2. Curry MP, O’Leary JG, Bzowej N, Muir AJ, Korenblat KM, Fenkel JM, Reddy KR, Lawitz E, Flamm SL, Schiano T, Teperman L. Sofosbuvir and velpatasvir for HCV in patients with decompensated cirrhosis. New England Journal of Medicine. 2015 Dec 31;373(27):2618-28.
3. Lee R, Kottilil S, Wilson E. Sofosbuvir/velpatasvir: a pangenotypic drug to simplify HCV therapy. Hepatology International. 2017 Mar;11:161-70.
4. Jackson WE, Everson GT. Sofosbuvir and velpatasvir for the treatment of hepatitis C. Expert review of gastroenterology & hepatology. 2017 Jun 3;11(6):501-5.
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