Bosutris 100mg Tablet contains Bosutinib as its active ingredient. A tyrosine kinase inhibitor (TKI) called bosutinib is used to treat specific forms of chronic myeloid leukemia (CML). It functions by preventing the BCR-ABL protein from promoting the aberrant development of white blood cells in people with CML.

Brand Name: Bosutris

Composition: Bosutinib

Mechanism of Action:

The Philadelphia chromosomal defect causes the fusion protein BCR-ABL tyrosine kinase to be inhibited by bosutinib. By blocking the signaling pathways required for leukemic cell growth and proliferation, this inhibition aids in disease control.

Uses:

Chronic myeloid leukemia

Dosage and Administration:

100 mg to 500 mg once daily, depending on the patient's medical condition and response to treatment. Tablets should be taken with food to improve absorption.

Side Effects:

• Diarrhea
• Nausea
• Vomiting
• Abdominal pain
• Fatigue
• Elevated liver enzymes
• Edema
• Headache
• Cough
• Fever
• Anemia

Safety Advise:

Liver  

As bosutinib can result on increased liver enzymes and, in certain situations, serious liver damage, liver function should be routinely evaluated. Kindly speak with your healthcare provider.

Kidney  

Patients with renal impairment may need to change their dosage. Kindly speak with your healthcare provider.

Pregnancy  

Not advised during pregnancy because of the possible risk to the fetus. Kindly speak with your healthcare provider.

Breast Feeding  

Using Bosutris 100 Tablet while nursing is most likely dangerous. Kindly speak with your healthcare provider.

Alcohol  

The safety of drinking alcohol while taking Bosutris 100 Tablets is unknown. Kindly speak with your healthcare provider.

Storage:

Keep at room temperature, usually in the range of 15°C to 30°C (59°F to 86°F). To keep the pills safe from light and moisture, keep them in their original container.

How to use this Medication?

Bosutinib is available as an oral tablet. It is typically taken once daily with food. Take bosutinib daily at approximately the same time. Pay close attention to the instructions on your prescription label, and ask your pharmacist or doctor to clarify any parts you don't understand. As prescribed, take bosutinib. Never take more or less of it, or take it more frequently than your doctor has suggested.

Do not break, chew, or crush the tablets; instead, swallow them whole. Avoid using your bare hands to handle any broken or crushed tablets.

References:

1.      Keller G, Schafhausen P, Brümmendorf TH. Bosutinib. Small Molecules in Oncology. 2010:119-27.

2.      Abbas R, Hsyu PH. Clinical pharmacokinetics and pharmacodynamics of bosutinib. Clinical pharmacokinetics. 2016 Oct;55:1191-204.

3.      Kantarjian HM, Cortes JE, Kim DW, Khoury HJ, Brümmendorf TH, Porkka K, Martinelli G, Durrant S, Leip E, Kelly V, Turnbull K. Bosutinib safety and management of toxicity in leukemia patients with resistance or intolerance to imatinib and other tyrosine kinase inhibitors. Blood, The Journal of the American Society of Hematology. 2014 Feb 27;123(9):1309-18.

4.      Stansfield L, Hughes TE, Walsh-Chocolaad TL. Bosutinib: a second-generation tyrosine kinase inhibitor for chronic myelogenous leukemia. Annals of Pharmacotherapy. 2013 Dec;47(12):1703-11.

Disclaimer:

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Marketer details

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Address: Mylan Pharmaceuticals Private Limited , Commercial Operations , Prestige Tech Park,Platina-3, 7th to 12th floor, Prestige Tech Park, Kadubesanahalli, Bangalore -560103

Country of origin: India