Regolieva 40mg Tablet contains Regorafenib, a multi-kinase inhibitor used in the treatment of certain cancers. It functions by preventing the activity of particular enzymes that contribute to the development and metastasis of cancer. 

Brand Name: Regolieva

Composition: Regorafenib

Mechanism of Action:

Regorafenib is a multi-kinase inhibitor that targets several kinases involved in tumor angiogenesis, oncogenesis, and the tumor microenvironment. By inhibiting these pathways, it reduces the blood supply to the tumor and effectively slows down or halts the growth and spread of cancer cells. This mechanism makes Regorafenib a valuable treatment option in certain types of cancers.

Uses:

• Colorectal Cancer
• Gastrointestinal Stromal Tumor
• Hepatocellular Carcinoma

Dosage and Administration:

For the first 21 days of the 28-day cycle, take 160 mg once day. Do not chew or crush tablets; instead, swallow them whole with water.

Side Effects:

• Fatigue
• Weakness
• Loss of appetite.
• Weight loss
• Diarrhea
• Nausea
• Vomiting
• Hand-foot skin reaction
• Hypertension
• Fever

Safety Advise:

Lungs  

The safety of Regolieva for individuals with lung issues is uncertain. Kindly speak with your healthcare provider.

Liver  

The safety of Regolieva for individuals with liver issues is uncertain. Kindly speak with your healthcare provider.

Kidney  

The safety of Regolieva for individuals with Kidney issues is uncertain. Kindly speak with your healthcare provider.

Pregnancy  

Regolieva should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

Breast Feeding  

Using Regolieva while nursing is most likely dangerous. Kindly speak with your healthcare provider.

Storage:

Keep at room temperature, between 20°C and 25°C. Steer clear of extreme humidity or heat. The tablets should be kept out of direct sunlight in their original packaging.

How to use this Medication?

Drink a glass of water along with this medication. Observe the medicine label's instructions. Avoid taking it more frequently than prescribed. Take this medication with food. Avoid taking grapefruit juice with it. Except as directed by your physician, do not discontinue taking.

Consult your pediatrician about this medication's use in kids. Extra caution could be required.

References:

1.      Ettrich TJ, Seufferlein T. Regorafenib. Small molecules in oncology. 2018:45-56.

2.      Strumberg D, Schultheis B. Regorafenib for cancer. Expert opinion on investigational drugs. 2012 Jun 1;21(6):879-89.

3.      Ettrich TJ, Seufferlein T. Regorafenib. Small Molecules in Oncology. 2014 Apr 23:185-96.

4.      Granito A, Forgione A, Marinelli S, Renzulli M, Ielasi L, Sansone V, Benevento F, Piscaglia F, Tovoli F. Experience with regorafenib in the treatment of hepatocellular carcinoma. Therapeutic Advances in Gastroenterology. 2021 May;14:17562848211016959.

Disclaimer:

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Marketer details

Name: Allieva Pharma Pvt Ltd

Address: 14/16/1 Site 4, Sahibabad Industrial Area, Ghaziabad, Uttar Pradesh 201010 Country of origin: India