Wepox 4000 IU Injection contains Human recombinant Erythropoetin Alfa, a synthetic version of a natural hormone called erythropoietin. It primarily serves to treat anemia, which is a low red blood cell count, brought on by chemotherapy, chronic renal disease, and other illnesses. The injection helps to lessen anemia symptoms like fatigue and weakness by encouraging the bone marrow to create more red blood cells.

Brand Name: Wepox

Composition: Human recombinant Erythropoetin Alfa

Mechanism of Action:

By attaching to erythropoietin receptors on erythroid progenitor cells in the bone marrow, human recombinant erythropoietin Alfa (Epoetin Alfa) increases the generation of red blood cells. This binding stimulates the proliferation and development of these progenitor cells by activating intracellular signaling pathways, including the JAK2/STAT5 pathway. Consequently, Epoetin Alfa improves hemoglobin levels and red blood cell synthesis, which improves the blood's ability to carry oxygen and reduces anemic symptoms.

Uses:

Anemia in Chronic Kidney Disease 

·         Anemia Due to Chemotherapy

       Anemia in HIV-Infected Patients

To   Reduce the Need for Blood Transfusions

Dosage and Administration:

Depending on the patient's health, wepox is injected intravenously (into a vein) or subcutaneously (under the skin). The patient's hemoglobin levels, the underlying reason of their anemia, and how well they respond to treatment all affect the dosage.

Side Effects:

·         Injection Site Reactions

·         Headache

·         Nausea

·         Fever

·         Vomiting

·         Joint Pain

·         Chills

·         Cough

·         High Blood Pressure

·         Dizziness

·         Weight Loss

·         Insomnia

Safety Advise:

Liver

Patients with liver illness should use Wepox 4000 Injection with caution. Wepox 4000 Injection dosage adjustments might be required. Kindly speak with your healthcare provider.

Kidney

Patients with renal illness should use Wepox 4000 Injection with caution. Wepox 4000 Injection dosage adjustments might be required. Kindly speak with your healthcare provider.

Pregnancy

Animal studies suggest that wepox 4000 injection could be harmful to the fetus, so it may not be safe to use during pregnancy. Before using it, discuss benefits and risks with your healthcare provider.

Breast Feeding

Using Wepox 4000 Injection while nursing is most likely dangerous. The medication may damage the developing baby if it enters the breastmilk, according to limited human data. Kindly speak with your healthcare provider.

Alcohol

It is unknown if drinking alcohol while using Wepox 4000 Injection is safe. Kindly speak with your healthcare provider.

Driving

You may get adverse reactions from Wepox 4000 Injection that might affect your driving. Kindly speak with your healthcare provider.

Storage:

Store in the refrigerator at 2°C to 8°C. Do not freeze it. Protect it from light and keep it out of reach of children.

References:

1.     Kashiv P, Malde S, Dubey S, Gupta S, Pawar T, Sejpal KN, Gurjar P, Pasari A, Balwani M, Bhawane A, Tolani P. A case of erythropoietin (EPO)-induced pure red cell aplasia and its treatment efficacy with desidustat. Cureus. 2024 Jun 9;16(6):e62022.

2.     Winearls CG. Recombinant human erythropoietin: 10 years of clinical experience. Nephrology, dialysis, transplantation: official publication of the European Dialysis and Transplant Association-European Renal Association. 1998 Jan 1;13(suppl_2):3-8.

3.     Jones EH. Recombinant human erythropoietin. American Journal of Health-System Pharmacy. 1989 Nov 1;46(11_suppl):S20-3.

4.     Das G. Epoetin alfa and beta differ in their erythropoietin isoform compositions and biological properties. British journal of haematology. 1998 Jan 1;100(1).

Disclaimer:

The main goal of Apothecare Wellness is to make sure that the information it provides to customers is correct, reliable, and reviewed by specialists. This website's contents and information are strictly for informational purposes. They are not meant to be used in place of expert medical advice, diagnosis, or care. Please consult your physician for guidance and ask any questions you may have about any condition or medication. If you read anything on Apothecare Wellness, do not discount or delay obtaining competent medical advice. Our goal is to enhance the doctor-patient relationship, not to take its place.

Marketer details

Name: Wockhardt Ltd

Address: Wockhardt Towers, Bandra Kurla Complex, Bandra (East), Mumbai 400051, Maharashtra, India

Country of origin: India