Nitrol 20mg Injection contains Mitoxantrone, a chemotherapeutic medication used to treat some cancers, such as acute myeloid leukemia, non-Hodgkin's lymphoma, and metastatic breast cancer. It is also used to decrease the course of multiple sclerosis.

Brand Name: Nitrol

Composition: Mitoxantrone

Mechanism of Action:

Mitoxantrone is a cytotoxic substance that works in a variety of ways. By putting itself in between base pairs, it intercalates into DNA, interfering with transcription and DNA replication and ultimately impeding cell division. Furthermore, it inhibits topoisomerase II, an enzyme necessary for DNA unwinding and repair, which stops cancer cells from mending damaged DNA and ultimately results in cell death. By decreasing hyperactive immune responses that target nerve cells, mitoxantrone also functions as an immunosuppressant in the therapy of multiple sclerosis (MS), aiding in the management of the disease's course.

Uses:

·       Breast Cancer

·       Non-Hodgkin’s Lymphoma

·       Acute Non-Lymphocytic Leukemia

·       Hormone-Refractory Prostate Cancer

·       Multiple Sclerosis

Dosage and Administration:

Given as an intravenous infusion by a healthcare professional. The body surface area, cancer kind, and response to treatment all affect dosage.

Side Effects:

·       Nausea

·       Vomiting

·       Diarrhea

·       Hair loss

·       Fatigue

·       Weakness

·       Menstrual irregularities

·       Absence of periods

·       Blue-green discoloration of urine, eyes, and nails.

Safety Advise:

Lungs  

The safety of Nitrol for individuals with lung issues is uncertain. Kindly speak with your healthcare provider.

Liver  

The safety of Nitrol for individuals with liver issues is uncertain. Kindly speak with your healthcare provider.

Kidney  

The safety of Nitrol for individuals with Kidney issues is uncertain. Kindly speak with your healthcare provider.

Pregnancy  

Nitrol should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

Breast Feeding  

Using Nitrol while nursing is most likely dangerous. Kindly speak with your healthcare provider.

Storage:

Keep out of direct sunlight and refrigerated between 2°C and 8°C. Avoid freezing.

How to use this Medication?

This medication is administered intravenously. A medical expert with specialized training administers it in a hospital or clinic. Inform your healthcare provider right away if you experience any odd feelings, such as pain, swelling, or burning, near the injection site.

Before every treatment, you will receive a customized MedGuide. Every time, make sure to carefully read this information.

Consult your pediatrician about this medication's use in kids. Extra caution could be required.

References:

1.     Fox EJ. Mechanism of action of mitoxantrone. Neurology. 2004 Dec 28;63(12_suppl_6):S15-8.

2.     Vollmer T, Stewart T, Baxter N. Mitoxantrone and cytotoxic drugs' mechanisms of action. Neurology. 2010 Jan 5;74(1_supplement_1):S41-6.

3.   Alberts DS, Peng YM, Bowden GT, Dalton WS, Mackel C. Pharmacology of mitoxantrone: mode of action and pharmacokinetics. Investigational new drugs. 1985 Jun;3:101-7.

4.     Hartung HP, Gonsette R, Morrissey S, Krapf H, Fazekas F. Mitoxantrone. InMultiple sclerosis therapeutics 1999 Sep 1 (pp. 351-364). CRC Press.

Disclaimer:

The main goal of Apothecare Wellness is to make sure that the information it provides to customers is correct, reliable, and reviewed by specialists. This website's contents and information are strictly for informational purposes. They are not meant to be used in place of expert medical advice, diagnosis, or care. Please consult your physician for guidance and ask any questions you may have about any condition or medication. If you read anything on Apothecare Wellness, do not discount or delay obtaining competent medical advice. Our goal is to enhance the doctor-patient relationship, not to take its place.

Marketer details:

Name: Neon Laboratories Ltd

Address: 140, Damji Samji Industrial Complex, Mahakali Caves Rd., Andheri(East), Mumbai-93.

Country of origin: India