Sigrima 420mg Injection contains Pertuzumab, a monoclonal antibody used to treat HER2-positive breast cancer, is an injection. For patients with HER2-positive breast cancer, either in the metastatic stage or as part of neoadjuvant/adjuvant therapy, it is frequently administered in conjunction with other drugs such trastuzumab and chemotherapy.

Brand Name: Sigrima

Composition: Pertuzumab

Mechanism of Action:

The HER2 receptor, a protein that is overexpressed in some breast tumors, is the target of pertuzumab. It prevents HER2 from dimerizing with other HER receptors by binding to a different epitope on the HER2 receptor than trastuzumab. The anticancer activity is enhanced by this dual blockage.

Uses:

HER2-positive metastatic breast cancer

Dosage and Administration:

Given as an infusion through the vein. Maintenance dosages of 420 mg every three weeks are administered after the initial loading dose of 840 mg.

Side Effects:

• Diarrhea
• Hair loss
• Nausea
• Vomiting
• Fever
• Fatigue
• Neutropenia
• Rash

Safety Advise:

Lungs  

The safety of Sigrima for individuals with lung issues is uncertain. Kindly speak with your healthcare provider.

Liver  

The safety of Sigrima for individuals with liver issues is uncertain. Kindly speak with your healthcare provider.

Kidney  

The safety of Sigrima for individuals with Kidney issues is uncertain. Kindly speak with your healthcare provider.

Pregnancy  

Sigrima should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

Breast Feeding  

Using Sigrima while nursing is most likely dangerous. Kindly speak with your healthcare provider. 

Storage:

Store in a refrigerator at 2°C to 8°C (36°F to 46°F). Do not freeze.

How to use this Medication?

This medication is administered intravenously. In a hospital or clinic, a medical practitioner administers it.

Consult your pediatrician about this medication's use in kids. Extra caution could be required.

Disclaimer:

The main goal of Apothecare Wellness is to make sure that the information it provides to customers is correct, reliable, and reviewed by specialists. This website's contents and information are strictly for informational purposes. They are not meant to be used in place of expert medical advice, diagnosis, or care. Please consult your physician for guidance and ask any questions you may have about any condition or medication. If you read anything on Apothecare Wellness, do not discount or delay obtaining competent medical advice. Our goal is to enhance the doctor-patient relationship, not to take its place.

Marketer details

Name: Zydus Lifesciences Ltd

Address: Zydus Corporate Park, 4Th Floor, B Wing, Plot No 103, Near Nirma University,S G Highway, Ahmedabad, 382481

Country of origin: India