Genryzon 60mg Injection contains Somatrogon, a growth hormone analog used in the treatment of growth hormone deficiency in children and adolescents.

Brand Name: Genryzon

Composition: Somatrogon

Mechanism of Action:

The properties of naturally occurring growth hormone are mimicked by this long-acting recombinant human growth hormone (rhGH). By encouraging protein synthesis, bone and muscle growth, and metabolism regulation, it promotes children's growth and development.

Uses:

Growth Hormone Deficiency

Dosage and Administration:

Somatrogon is usually given once a week, with the dosage being determined by the patient's weight. The healthcare professional will decide on the precise dosage. Genryzon is administered subcutaneously, usually in the upper arm, belly, or thigh.

Side Effects:

• Diarrhea
• Fatigue
• Nausea
• Vomiting
• Decreased appetite
• Abdominal pain
• Anemia
• Neutropenia (low levels of neutrophils)
• Increased liver enzymes (AST and ALT)
• Headache

Safety Advise:

Liver  

Somatrogon can result in increased liver enzymes and hepatotoxicity, liver function tests must to be conducted on a frequent basis. Kindly speak with your healthcare provider.

Kidney  

Patients who have severe renal impairment should use this medication with cautiously. Kindly speak with your healthcare provider.

Pregnancy  

Somatrogon can harm an unborn baby, so it should not be used during pregnancy. Kindly speak with your healthcare provider.

Breast Feeding  

Breastfeeding should be avoided as the drug may pass into breast milk and harm the nursing infant. Kindly speak with your healthcare provider.

Driving  

It is unknown if Somatrogon affects one's capacity to operate a vehicle. So, use with cautiously. Kindly speak with your healthcare provider.

Storage:

Store Genryzon Injection at controlled room temperature (between 20-25°C) and protect it from light. Do not freeze.

How to use this medication?

Usually given once a week on the same day, somatrogon is a liquid solution in a prefilled injectable pen for subcutaneous injection. Use the drug exactly as prescribed, pay close attention to the directions on your prescription, and ask your doctor or pharmacist any questions.

Pens and needles should never be shared. Used pens and needles should be disposed of in a receptacle that can withstand punctures and is out of children's reach. For information on how to get rid of the puncture-resistant container, speak with your pharmacist or doctor.

References:

1.   Lamb YN. Somatrogon: first approval. Drugs. 2022 Feb;82(2):227-34.

2.   Deal CL, Steelman J, Vlachopapadopoulou E, Stawerska R, Silverman LA, Phillip M, Kim HS, Ko C, Malievskiy O, Cara JF, Roland CL. Efficacy and safety of weekly somatrogon vs daily somatropin in children with growth hormone deficiency: a phase 3 study. The Journal of Clinical Endocrinology & Metabolism. 2022 Jul 1;107(7):e2717-28.

3.   Zadik Z, Zelinska N, Iotova V, Skorodok Y, Malievskiy OA, Mauras N, Valluri SR, Pastrak A, Rosenfeld RG, Taylor CT, Nijher M. OR21-04 Long-term Efficacy And Safety Of Once-weekly Somatrogon In Pediatric Subjects With Growth Hormone Deficiency: Results From Up To 8 Years Of Somatrogon Treatment. Journal of the Endocrine Society. 2023 Oct;7(Supplement_1):bvad114-1522.

Disclaimer:

The main goal of Apothecare Wellness is to make sure that the information it provides to customers is correct, reliable, and reviewed by specialists. This website's contents and information are strictly for informational purposes. They are not meant to be used in place of expert medical advice, diagnosis, or care. Please consult your physician for guidance and ask any questions you may have about any condition or medication. If you read anything on Apothecare Wellness, do not discount or delay obtaining competent medical advice. Our goal is to enhance the doctor-patient relationship, not to take its place.

Marketer details

Name: Pfizer Ltd

Address: The Capital, 1802, 18th Floor, Plot No. C-70, ‘G’ Block , Bandra Kurla Complex, Bandra East , Mumbai – 400051.

Country of origin: India