Zavicefta Injection contains Ceftazidime and Avibactam is a combination antibiotic used to treat serious bacterial infections, especially those resistant to other antibiotics

Brand Name: Zavicefta

Composition: Ceftazidime and Avibactam

Mechanism of Action:

Ceftazidime is a third-generation cephalosporin antibiotic that causes bacterial cell death by preventing the formation of bacterial cell walls whereas Avibactam is a beta-lactamase inhibitor that increases the antibiotic's effectiveness against resistant strains by shielding ceftazidime from being broken down by beta-lactamase enzymes generated by resistant bacteria.

Uses:

• Pneumonia
• Urinary tract infections (UTIs)
• Intra abdominal infection

Dosage and Administration:

Administered intravenously, Dosage varies based on the type and severity of the infection, renal function, and patient age. It is usually given every 8 hours.

Side Effects:

·       Nausea

·       Vomiting

·       Diarrhea

·       Rash

·       Headache

·       Allergic reactions

·       Seizures

·       Thrombocytosis

Safety Advise:

Allergy  

Screen for allergies to Zavicefta, other carbapenems, or beta-lactam antibiotics, leading to serious allergic reactions. Kindly speak with your healthcare provider.

Kidney  

Zavicefta is primarily excreted by the kidneys, so dose adjustments are required in patients with renal impairment. Kindly speak with your healthcare provider.

Liver  

Liver function tests should be monitored during prolonged treatment, especially in patients with liver disease, as meropenem can cause elevated liver enzymes. Kindly speak with your healthcare provider.

Pregnancy  

Use Zavicefta during pregnancy only if clearly needed and under medical supervision, as its safety during pregnancy is not fully established.  Kindly speak with your healthcare provider.

Breast Feeding  

Caution is advised during breastfeeding since the drug can pass into breast milk. Kindly speak with your healthcare provider.

Storage:

Store in a cool and dry place away from sunlight. Store the vials at room temperature before reconstitution. Once reconstituted, the solution should be used within a specific time frame as recommended by the manufacturer to ensure stability and effectiveness.

How to use this medication?

This medication is administered through an injection into a vein, usually by a healthcare professional in a hospital or clinic.

If you need to use this medication at home, you will be trained on how to prepare and administer it. Follow the instructions exactly as directed and take it according to the prescription label at the same time each day. Continue using it unless your healthcare provider advises you to stop.

Used needles and syringes should be disposed of in a special sharps container, not in regular trash. If you don't have one, contact your pharmacist or healthcare provider to obtain one.

Consult your healthcare provider regarding its use in children. It may be prescribed for newborns for specific conditions, but certain precautions are necessary.

References:

1.      Berkhout J, Melchers MJ, van Mil AC, Seyedmousavi S, Lagarde CM, Schuck VJ, Nichols WW, Mouton JW. Pharmacodynamics of ceftazidime and avibactam in neutropenic mice with thigh or lung infection. Antimicrobial agents and chemotherapy. 2016 Jan;60(1):368-75.

2.      Zhanel GG, Lawson CD, Adam H, Schweizer F, Zelenitsky S, Lagacé-Wiens PR, Denisuik A, Rubinstein E, Gin AS, Hoban DJ, Lynch JP. Ceftazidime-avibactam: a novel cephalosporin/β-lactamase inhibitor combination. Drugs. 2013 Feb;73:159-77.

3.      Shirley M. Ceftazidime-avibactam: a review in the treatment of serious gram-negative bacterial infections. Drugs. 2018 Apr;78:675-92.

4.      Matesanz M, Mensa J. Ceftazidime-avibactam. Revista Española de Quimioterapia. 2021;34(Suppl1):38.

Disclaimer:

The main goal of Apothecare Wellness is to make sure that the information it provides to customers is correct, reliable, and reviewed by specialists. This website's contents and information are strictly for informational purposes. They are not meant to be used in place of expert medical advice, diagnosis, or care. Please consult your physician for guidance and ask any questions you may have about any condition or medication. If you read anything on Apothecare Wellness, do not discount or delay obtaining competent medical advice. Our goal is to enhance the doctor-patient relationship, not to take its place.

Marketer details

Name: Pfizer Ltd

Address: The Capital, 1802, 18th Floor, Plot No. C-70, ‘G’ Block , Bandra Kurla Complex, Bandra East , Mumbai – 400051.

Country of origin: India