Ematra Softgel Capsule contains Tretinoin (All-Trans Retinoic Acid), which is primarily used in the treatment of acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia. Tretinoin functions by encouraging immature blood cells to differentiate into healthy, mature ones.

Brand Name: Ematra

Composition: Tretinoin

Mechanism of Action:

Tretinoin promotes the differentiation of immature carcinogenic cells and inhibits their growth by acting on certain receptors in these cells. Tretinoin aids in breaking the block in promyelocyte differentiation caused by the PML-RARα fusion protein in APL, allowing the leukemic cells to develop into viable blood cells.

Uses:

Acute promyelocytic leukemia

Dosage and Administration:

Typically, two divided dosages of around 45 mg/m² per day are advised. The patient's weight, health, and course of therapy will all affect the precise dosage. usually taken for 90 days or as directed by a doctor.

Side Effects:

• Headache
• Fever
• Nausea
• Vomiting
• Bone pain
• Dry lips
• Hair loss
• Visual impairment
• Skin dryness or rash
• Leukocytosis

Safety Advise:

Liver  

While liver damage is a possibility during treatment, routine liver function tests are required. Kindly speak with your healthcare provider.

Kidney  

While renal damage is a possibility during treatment, routine renal function tests are required. Kindly speak with your healthcare provider.

Pregnancy  

Women of childbearing age should refrain from getting pregnant while receiving treatment and for a certain amount of time following it because retinoin is extremely teratogenic (may cause birth problems). Kindly speak with your healthcare provider.

Breast Feeding  

It may be dangerous to take a Ematra capsule while nursing because it could harm the unborn child. Kindly speak with your healthcare provider.

Alcohol  

The safety of using Ematra Capsule with alcohol is unknown. Kindly speak with your healthcare provider.

Storage:

Store at room temperature, typically between 15°C and 30°C (59°F and 86°F). Keep in a dry place, away from direct light and moisture.

How to use this Medication?

Drink a glass of water along with this prescription. Observe the medicine label's instructions. Take your prescription drug on a regular basis. Avoid taking it more frequently than prescribed. Except as directed by your care team, do not stop taking.

Discuss the usage of this drug in children with your care team. Precautions are necessary even if this drug may be recommended for specific illnesses.

References:

1.     Gillis JC, Goa KL. Tretinoin: a review of its pharmacodynamic and pharmacokinetic properties and use in the management of acute promyelocytic leukaemia. Drugs. 1995 Nov;50:897-923.

2.     Warrell Jr RP, Frankel SR, Miller Jr WH, Scheinberg DA, Itri LM, Hittelman WN, Vyas R, Andreeff M, Tafuri A, Jakubowski A, Gabrilove J. Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans-retinoic acid). New England Journal of Medicine. 1991 May 16;324(20):1385-93.

3.     Mahmoud HH, Hurwitz CA, Roberts WM, Santana VM, Ribeiro RC, Krance RA. Tretinoin toxicity in children with acute promyelocytic leukaemia. The Lancet. 1993 Dec 4;342(8884):1394-5.

Disclaimer:

The main goal of Apothecare Wellness is to make sure that the information it provides to customers is correct, reliable, and reviewed by specialists. This website's contents and information are strictly for informational purposes. They are not meant to be used in place of expert medical advice, diagnosis, or care. Please consult your physician for guidance and ask any questions you may have about any condition or medication. If you read anything on Apothecare Wellness, do not discount or delay obtaining competent medical advice. Our goal is to enhance the doctor-patient relationship, not to take its place.

Marketer details

Name: Emcure Pharmaceuticals Ltd

Address: 255/2, Hinjawadi, Pune - 411057, India

Country of origin: India