Arsenam 10mg Injection contains Arsenic Trioxide as its active ingredient. It is primarily used in the treatment of acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML). Arsenic trioxide functions by encouraging the differentiation of immature blood cells and causing cells with cancer to undergo apoptosis, or programmed cell death.

Brand Name: Arsenam

Composition: Arsenic Trioxide

Mechanism of Action:

By encouraging oxidative stress, harming the mitochondria of the cells, and blocking certain proteins necessary for cancer cell survival, arsenic trioxide targets and triggers apoptosis in leukemic cells. Additionally, it influences leukemia cells' differentiation, which results in their development and ultimate demise.

Uses:

Acute promyelocytic leukemia

Dosage and Administration:

The dosage and administration plan depend on body weight, patient condition, and the treatment stage. given as an intravenous infusion while being watched over by a medical practitioner.

Side Effects:

• Fatigue
• Nausea
• Vomiting
• Diarrhea
• Skin rash
• Hyperglycemia
• Dizziness
• Fever
• Itching

Safety Advise:

Liver  

Caution in patients with impaired liver function, as dose adjustments may be necessary. Kindly speak with your healthcare provider.

Kidney  

Caution in patients with impaired kidney function, as dose adjustments may be necessary. Kindly speak with your healthcare provider.

Pregnancy  

Since it could harm the fetus, it is not advised to use it during pregnancy. Kindly speak with your healthcare provider.

Breast Feeding  

There is no information available on using Arsenam 10mg Injection while nursing. Kindly speak with your healthcare provider.

Alcohol  

The safety of drinking alcohol while taking Arsenam 10mg Injection is unknown. Kindly speak with your healthcare provider.

Storage:

Store between 2°C and 8°C (36°F and 46°F). Do not freeze. Protect from light.

How to use this Medication?

In a clinic or doctor's office, a doctor or nurse will inject a solution (liquid) of arsenic trioxide into a patient's vein. Usually administered over a period of one to two hours, arsenic trioxide injections can last up to four hours if adverse effects occur throughout the infusion. Typically, it is administered once day for a predetermined amount of time.

References:

1.      Miller Jr WH, Schipper HM, Lee JS, Singer J, Waxman S. Mechanisms of action of arsenic trioxide. Cancer research. 2002 Jul 15;62(14):3893-903.

2.      Antman KH. Introduction: the history of arsenic trioxide in cancer therapy. The oncologist. 2001 Apr 1;6(S2):1-2.

3.      Litzow MR. Arsenic trioxide. Expert Opinion on Pharmacotherapy. 2008 Jul 1;9(10):1773-85.

4.      Davison K, Mann KK, Miller Jr WH. Arsenic trioxide: mechanisms of action. InSeminars in hematology 2002 Apr 1 (Vol. 39, No. 2, pp. 3-7). WB Saunders.

Disclaimer:

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Marketer details

Name: GLS Pharma Ltd.

Address: R-4, Khirki Main Road, Malviya Nagar New Delhi- 110 017, (India)

Country of origin: India