Tacrograf 1mg Capsule contains tacrolimus, an immunosuppressive medication used primarily to prevent organ rejection in patients who have undergone a kidney, liver, or heart transplant. In order to stop the immune system from attacking the transplanted organ, it suppresses it.

Brand Name: Tacrograf

Composition: Tacrolimus

Mechanism of Action:

Tacrolimus suppresses the enzyme calcineurin, which is implicated in immune system T-cell activation. Tacrolimus prevents organ rejection by lowering the immune response through blocking this route.

Uses:

Prevention of organ rejection in transplant patients (kidney, liver, or heart transplants)

Dosage and Administration:

The capsule should be swallowed whole with water, not crushed or chewed. Usually taken once daily in the morning on an empty stomach.

Side Effects:

• Tremors
• Rash
• Headache
• Nausea
• Vomiting
• Dizziness
• Fatigue
• Diarrhea
• High blood pressure
• Kidney dysfunction
• High blood sugar levels

Safety Advise:

Kidney  

Monitor kidney function regularly, as tacrolimus can cause nephrotoxicity. Kindly speak with your healthcare provider.

Liver  

Monitor liver function regularly, as tacrolimus can cause liver impairement. Kindly speak with your healthcare provider.

Pregnancy  

Tacrograf should be used during pregnancy only if clearly needed, Kindly speak with your healthcare provider.

Breast Feeding  

Using Tacrograf 1mg Capsule while nursing is most likely dangerous. Kindly speak with your healthcare provider.

Alcohol  

Tacrograf 1mg Capsule should not be taken with alcohol. Kindly speak with your healthcare provider.

Storage:

Store Tacrograf capsules at a temperature between 15°C and 30°C (59°F to 86°F). Keep the capsules in the original packaging to protect them from light and moisture. Keep out of reach of children.

How to use this Medication?

Tacrolimus comes in various forms and should be taken as directed, with immediate-release capsules taken twice daily and extended-release forms taken once daily on an empty stomach. Always take tacrolimus at the same time each day as directed by your doctor.

Do not split, chew, or crush the extended-release capsules; instead, swallow them whole with water. The immediate-release capsules should not be opened or crushed.

References:

1.      Markham ON. tacrolimus extended release capsules 0.5 mg, 1 mg, 3 mg and 5 mg capsules.

2.      Markham ON. Pr Advagraf®.

3.      Lynas K. Product Update. Canadian Pharmacists Journal. 2008 Jul 1;141(4):216.

4.      Kelly PA, Burckart GJ, Venkataramanan R. Tacrolimus: a new immunosuppressive agent. American journal of health-system pharmacy. 1995 Jul 1;52(14):1521-35.

5.      Bowman LJ, Brennan DC. The role of tacrolimus in renal transplantation. Expert opinion on pharmacotherapy. 2008 Mar 1;9(4):635-43.

Disclaimer:

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Marketer details

Name: Eris Lifesciences Ltd

Address: 8th Floor, Commerce House IV, Prahladnagar, Ahmedabad – 380015 Gujarat, India

Country of origin: India