Rozel 60mg Injection contains Denosumab, a monoclonal antibody used primarily in the treatment of bone-related conditions. 

Brand Name: Rozel

Composition: Denosumab

Mechanism of Action:

Denosumab is a RANK ligand (RANKL) inhibitor that binds to and inactivates RANKL, a protein essential for the formation, function, and survival of osteoclasts (cells that break down bone). By inhibiting RANKL, Denosumab reduces bone resorption and increases bone density, thereby lowering the risk of fractures.

Uses:

·         Osteoporosis

·         Bone Loss

·         Giant Cell Tumor of Bone

·         Hypercalcemia of Malignancy

Dosage and Administration:

60 mg subcutaneously once every 6 months for osteoporosis; other conditions may have different dosing schedules. Administered as a subcutaneous injection in the upper arm, upper thigh, or abdomen.

Side Effects:

·         Back pain

·         Musculoskeletal pain

·         High cholesterol

·         Urinary tract infections

·         Rash

·         Hypocalcemia (low blood calcium levels)

·         Osteonecrosis of the jaw

·         Femur fractures

·         Hair loss

·         Nerve Pain

Safety Advise:

Kidney  

Those with serious kidney problems should take Rozel 60 Injection carefully. It could be necessary to modify the dosage of Rozel 60 Injection. Kindly speak with your Healthcare provider.

Liver  

Those with serious liver problems should take Rozel 60 Injection carefully. It could be necessary to modify the dosage of Rozel 60 Injection. Kindly speak with your Healthcare provider.

Pregnancy  

Contraindicated in pregnancy due to the risk of fetal harm. Kindly speak with your Healthcare provider.

Breast Feeding  

Given that the medication may enter the breast milk and injure the unborn child, Rozel 60 Injection is most likely dangerous to use while nursing. Kindly speak with your Healthcare provider.

Alcohol  

When using Rozel 60 Injection with alcohol, caution is recommended. Kindly speak with your Healthcare provider.

Storage:

Store in a refrigerator at 2°C to 8°C. Do not freeze. Keep in the original packaging to protect from light and out of reach of children.

How to use this Medication?

This medication is injected subcutaneously. It is delivered at a hospital or clinic by a medical professional.

You will receive a personalized MedGuide prior to every treatment. Every time, make sure to carefully read this information.

Consult your pediatrician about Prolia and the usage of this medication in young patients. There might be a need for extra caution. Consult your physician about the usage of Xgeva in young patients. Precautions do apply even though this medication may be administered for specific diseases to youngsters as young as 13 years old.

References:

1. Hanley DA, Adachi JD, Bell A, Brown V. Denosumab: mechanism of action and clinical outcomes. International journal of clinical practice. 2012 Dec;66(12):1139-46.

2. Pageau SC. Denosumab. InMAbs 2009 May 1 (Vol. 1, No. 3, pp. 210-215). Taylor & Francis.

3. Cummings SR, Martin JS, McClung MR, Siris ES, Eastell R, Reid IR, Delmas P, Zoog HB, Austin M, Wang A, Kutilek S. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. New England Journal of Medicine. 2009 Aug 20;361(8):756-65.

4. Narayanan P. Denosumab: A comprehensive review. South Asian journal of cancer. 2013 Oct;2(04):272-7.

Disclaimer:

The main goal of Apothecare Wellness is to make sure that the information it provides to customers is correct, reliable, and reviewed by specialists. This website's contents and information are strictly for informational purposes. They are not meant to be used in place of expert medical advice, diagnosis, or care. Please consult your physician for guidance and ask any questions you may have about any condition or medication. If you read anything on Apothecare Wellness, do not discount or delay obtaining competent medical advice. Our goal is to enhance the doctor-patient relationship, not to take its place.

Marketer details

Name: Intas Pharmaceuticals Ltd

Address: Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.

Country of origin: India