Cazanat 40mg Tablet contains Cabozantinib as its active ingredient. By blocking many receptor tyrosine kinases (RTKs) involved in tumor growth, metastasis, and angiogenesis, the tyrosine kinase inhibitor (TKI) cabotinib is used to treat a variety of cancer types.

Brand Name: Cazanat

Composition: Cabozantinib

Mechanism of Action:

Multiple tyrosine kinases, such as MET, VEGFR, and RET, which are implicated in several pathways essential for tumor cell development and angiogenesis (blood vessel creation), are inhibited by cabotinib. Cabozantinib can decrease the blood supply to tumors and impede the growth and spread of cancer cells by blocking these kinases.

Uses:

• Liver Cancer
• Kidney Cancer
• Medullary thyroid Cancer

Dosage and Administration:

Depending on the type of cancer being treated and patient characteristics like liver or renal function, the usual dosage for Cazanat is 60 mg once daily. It must be taken at least two hours before or after a meal, on an empty stomach.

Side Effects:

• Diarrhea
• Fatigue
• Nausea
• Vomiting
• Anemia
• Decreased appetite
• Weight loss
• Elevated liver enzymes
• Hypertension (high blood pressure)
• Palmar-plantar erythrodysesthesia (hand-foot syndrome)

Safety Advise:

Liver  

For patients with liver issues, dose modifications might be necessary, and routine liver function monitoring is advised. Kindly speak with your healthcare provider.

Kidney  

For patients with kidney issues, dose modifications might be necessary, and routine renal function monitoring is advised. Kindly speak with your healthcare provider.

Pregnancy  

Cabozantinib is not advised during pregnancy since it may harm the fetus. Kindly speak with your healthcare provider.

Breast Feeding  

Cazanat 40mg Tablet is probably unsafe to use during breastfeeding. Kindly speak with your healthcare provider.

Alcohol  

The safety of combining alcohol with Cazanat 40mg Tablet is unknown. Kindly speak with your healthcare provider.

Storage:

Store at room temperature between 15°C and 30°C (59°F and 86°F). Keep in a dry place, protected from direct light and moisture.

How to use this Medication?

Cabozantinib is a pill that is typically given once a day, either one hour before or two hours after meals, on an empty stomach. Pay close attention to what your doctor tells you, and don't change the dosage without consulting your doctor.

Drink a full glass of water and swallow the tablets whole. Avoid opening, crushing, chewing, and splitting them.

References:

1.      Lacy SA, Miles DR, Nguyen LT. Clinical pharmacokinetics and pharmacodynamics of cabozantinib. Clinical pharmacokinetics. 2017 May;56:477-91.

2.    Abou-Alfa GK, Meyer T, Cheng AL, El-Khoueiry AB, Rimassa L, Ryoo BY, Cicin I, Merle P, Chen Y, Park JW, Blanc JF. Cabozantinib in patients with advanced and progressing hepatocellular carcinoma. New England Journal of Medicine. 2018 Jul 5;379(1):54-63.

3.    Maroto P, Porta C, Capdevila J, Apolo AB, Viteri S, Rodriguez-Antona C, Martin L, Castellano D. Cabozantinib for the treatment of solid tumors: a systematic review. Therapeutic advances in medical oncology. 2022 Jun;14:17588359221107112.

4.      Fallahi P, M Ferrari S, Di Bari F, Materazzi G, Benvenga S, Miccoli P, Antonelli A. Cabozantinib in thyroid cancer. Recent Patents on Anti-Cancer Drug Discovery. 2015 Sep 1;10(3):259-69.

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Marketer details

Name: Natco Pharma Ltd

Address: Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India

Country of origin: India